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Photo of Colby Weeks

Colby Weeks

Assistant Professor
Faculty of Sciences

McKay Classroom Building Room 138D

(808) 675-3690

Professional Development

  • PhD, University of California, Irvine, 2006

Research Interest

All things microbiology! I specialize in antimicrobial peptides, and have many projects exploring the antimicrobial activity of plants found on the island of Oahu.

Current Classes

  • Bio100
  • Bio112
  • Bio220 & lab
  • Bio376 & lab
  • Bio442 & lab


Positive Selection of Arginine in α-Defensins: Attenuation of Bactericidal Activity by Arg→Lys Substitutions is Dependent on Peptide Primary Structure Infect Immun. 2009 Nov; 77 (11):5035-43.

Weeks CS, Llenado RA, Cocco MJ, Young S, Qu X, and Ouellette AJ

Anionic Amino Acids near the Pro-α-Defensin N-terminus Mediate Inhibition of Bactericidal Activity in Mouse Pro-Cryptdin-4

J Biol Chem. 2009 Mar 13; 284 (11): 6826-21.

Figueredo S, Weeks CS, Young S, and Ouellette AJ

Matrix Metalloproteinase-7 Activation of Mouse Paneth Cell Pro-a-Defensins: Ser43↓Ile44 Proteolysis Enables Membrane Disruptive Activity. J Biol Chem. 2006 Sep 29; 281 (39): 28932-42.

Weeks CS, Hiroki T, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco M, and Ouellette AJ

Structure-Activity Determinants in Paneth Cell a-Defensins: Loss-of-Function in Mouse Cryptdin-4 by Charge-Reversal at Arginine Residue Positions. J Biol Chem. 2004 Mar 19; 279 (12): 11976-83

Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, and Ouellette AJ.